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Married Edmund Tudor, 1st Earl of Richmond and half brother of King Henry VI in 1455. Their son Henry was born in Pembroke Castle in 1457, three months after Tudor's death from the plague. She stayed with her son in Pembroke during the initial years of the Wars of the Roses. Margaret was deeply involved in the bitter struggle between the houses of York and Lancaster and was determined that her Lancastrian son would become king. She was married twice more, to Sir Henry Stafford and later to Thomas, Lord Stanley, who in 1485 helped her son obtain the throne. She re-founded God's House, Cambridge as Christ's College and has been honoured ever since. She also founded St John's College, Cambridge.