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A grandson of William Cecil, 1st Baron Burghley, Queen Elizabeth I's Minister, Edward Cecil entered military service in about 1596. He served under Sir Francis Vere in the Low Countries, during the wars between the Dutch and Spanish. In 1600 he commanded a body of 1,000 men which successfully relieved Ostend from a Spanish siege, and was knighted by Queen Elizabeth I on his return. The following year he went on to serve as colonel of a regiment of English horse under the brilliant Dutch commander, Count Maurice of Nassau (later Prince of Orange). Through the patronage of George Villiers, Duke of Buckingham, Cecil was given command of an expedition to the coast of Spain in 1625. It was Cecil's first independent command and he was completely ignorant of naval affairs.